Post by mtcowgirl on Nov 15, 2019 14:55:59 GMT -5
OK can someone please explain this to me a little bit better. I finally got around to testing our cows for the A2/A2 I went with UCDavis. The cows all came back with A2/I status, with the following statement
In the A2C nomenclature for A2 genotyping, the Beta Casein above corresponds to A2/A2
What does that mean? I have not studied into a2 in recent years becuase of being busy with kids. So I was wondering if someone could explain to me what this means. Does this mean they are a2/a2? and what does the I mean in the variants. Is this a variant within a2?
Below is more info under the aboove comment. If that helps.
Beta Casein (A2 Genotyping)* - milk yield and protein content. The A2 variant has been shown to have a positive association with milk yield and
protein content. The expanded beta casein test reflected in this report detects variants A1, A2, A3, B, C, D, E, F, G, H1, H2, I, K and L.
Based on the aminoacid present in position 67 these variants can be classified into 2 groups - A1 and A2. Variants in the A1-group (Histidine) are
A1, B, C, F and G. Variants in the A2-group (Proline) are A2, A3, D, E, H1, H2, I, K and L. The levels of bioactive peptide beta-casomorphin 7
(BCM7) produced from the metabolism of beta casein is several-fold higher for variants in the A1 group than in the A2 group. Higher levels of
BCM7 have been associated with negative health effects in humans. Relative to levels of BCM7 production, variants within each group behave
similarly but may differ in other properties.
Introduction
The solids found in cow’s milk are composed of fat, protein, lactose and minerals. Beta-casein is one of six milk proteins and is produced by the CSN2 gene. Fifteen genetic variants of CSN2 are known which cause changes of certain amino acids in the beta-casein protein and alter its properties. Based on the amino acid in position 67 these variants can be classified into 2 groups - A1 and A2. Variants that belong to the A1 group (His67) are A1, B, C, F and G. Variants that belong to the A2 group (Pro67) are A2, A3, H1, H2, I, J, K and L. The levels of bioactive peptide beta-casomorphin 7 (BCM7) produced from the metabolism of beta casein is several-fold higher for variants in the A1 group than in the A2 group. Higher levels of BCM7 have been associated with negative health effects in humans.
In the A2C nomenclature for A2 genotyping, the Beta Casein above corresponds to A2/A2
What does that mean? I have not studied into a2 in recent years becuase of being busy with kids. So I was wondering if someone could explain to me what this means. Does this mean they are a2/a2? and what does the I mean in the variants. Is this a variant within a2?
Below is more info under the aboove comment. If that helps.
Beta Casein (A2 Genotyping)* - milk yield and protein content. The A2 variant has been shown to have a positive association with milk yield and
protein content. The expanded beta casein test reflected in this report detects variants A1, A2, A3, B, C, D, E, F, G, H1, H2, I, K and L.
Based on the aminoacid present in position 67 these variants can be classified into 2 groups - A1 and A2. Variants in the A1-group (Histidine) are
A1, B, C, F and G. Variants in the A2-group (Proline) are A2, A3, D, E, H1, H2, I, K and L. The levels of bioactive peptide beta-casomorphin 7
(BCM7) produced from the metabolism of beta casein is several-fold higher for variants in the A1 group than in the A2 group. Higher levels of
BCM7 have been associated with negative health effects in humans. Relative to levels of BCM7 production, variants within each group behave
similarly but may differ in other properties.
Introduction
The solids found in cow’s milk are composed of fat, protein, lactose and minerals. Beta-casein is one of six milk proteins and is produced by the CSN2 gene. Fifteen genetic variants of CSN2 are known which cause changes of certain amino acids in the beta-casein protein and alter its properties. Based on the amino acid in position 67 these variants can be classified into 2 groups - A1 and A2. Variants that belong to the A1 group (His67) are A1, B, C, F and G. Variants that belong to the A2 group (Pro67) are A2, A3, H1, H2, I, J, K and L. The levels of bioactive peptide beta-casomorphin 7 (BCM7) produced from the metabolism of beta casein is several-fold higher for variants in the A1 group than in the A2 group. Higher levels of BCM7 have been associated with negative health effects in humans.